Deep Vein Thrombosis
Deep Vein Thrombosis is the formation of a thrombus (blood clot)
within a deep vein, commonly in the thigh or calf. It is not unusual
for the blood to clot from time to time, but most clots go unnoticed.
They are small, cause no symptoms, are dissolved over time by the
body, and need no treatment. There are times, however, when the body
cannot dissolve the clot on its own, or the clot causes health problems
that must be treated. Clots that interfere with the normal flow of
blood or may affect organs that are vital to health and life must
be diagnosed and treated early to avoid serious illness or death.
The deep veins that lie near the center of the leg do most of the
work of the venous system. Nearly all – 85 percent – of
the circulating blood is returned to the heart through these veins.
DVT – the formation of a clot (or thrombus) in any one of these
veins – can be a very serious problem. Typically, the clot
comes on suddenly and without warning. If not treated, DVT can block
the blood supply to the legs and cause tissue death or gangrene that
requires the removal (amputation) of all or part of the leg. A related
condition, called Venous Occlusive Disease, is diagnosed and treated
the same as DVT. DVT also can lead to valve damage in the vein and
a chronic condition, called venous stasis disease that is difficult
to treat.
Deep
Vein Thrombosis |
With early treatment, patients with DVT can reduce their chances
of developing a life threatening pulmonary embolism (PE) to less
than 1 percent. The Interventional Radiologists of RANK can treat
both DVT and PE through catheter-directed thrombolysis, in which
blood clots are dissolved without surgery through the injection of "clot
busting" drugs directly on the clot through a catheter.
Facts:
The tendency of blood cells to "stick together" and form
clots depends on a combination of two factors:
- Sluggish Blood Flow. Sitting still or lying down for a long time,
such as on an airplane ride, can slow down the flow of blood. Prolonged
bed rest after surgery or injury is especially likely to contribute
to blood clots.
- Clotting factors – substances in the blood that regulate
the formation of clots – may increase after an operation
or injury, or during pregnancy. Talking birth control pills may
increase a woman’s risk of forming blood clots. Severe infection,
an increase in red cells, certain types of cancer and an injury
to the vein itself are other factors that can contribute to the
formation of blood clots.
DVT may be related to prolonged periods of bed rest or inactivity,
injury to the vein, surgery or pregnancy.
In addition to restricting the flow of blood, there is risk that
the clot may break off, travel through the heart and get trapped
in the lung (pulmonary embolism) – a potentially fatal complication.
Risk Factors:
A family history
- Increasing age that results in a loss of elasticity in the veins
and their valves
- Pregnancy
- Illness or injury
- Prolonged periods of inactivity – sitting, standing or
bed rest
- Hypertension, diabetes, high cholesterol or other conditions
that affect the health of the cardiovascular system
- Smoking
- Obesity
Diagnosis:
he presence of deep vein thrombosis is most often confirmed by ultrasound. Ultrasound is
a painless procedure in which a radiologist or technician moves an
instrument (transducer/receiver) about the size and shape of a computer
mouse across the outside surface of the skin. Sound waves are transmitted
through the skin and allow the technician to "see" the
size, shape and texture of the patient’s veins. A picture is
displayed on a computer screen as the radiologist or technician takes
the ultrasound.
Your interventional radiologist will use ultrasound to assess the
venous anatomy, vein valve function, and venous blood flow changes,
which can assist in diagnosing deep vein thrombosis. The doctor will
map the greater saphenous vein and examine the deep venous systems
to determine if the veins are open and to pinpoint any thrombus formation.
The saphenous vein, which runs the length of the thigh, is one of
the major veins of the leg.
Magnetic Resonance (MR) Angiography is a non-invasive diagnostic
technique that creates an image of the arteries in the brain. A magnetic
resonance (MR) scanner uses harmless but powerful magnetic fields
and radio waves to create detailed images of the body's tissues.
Computed Tomograph (CT) Angiography uses computers to generate
detailed pictures of the blood vessels, and can be helpful for planning
of interventional procedures.
Treatment Options:
Traditional treatments for DVT include:
- bed rest
- elevation of the affected limb
- pressure stockings, and
- drugs to prevent blood from clotting. These drugs, called anticoagulants,
keep the clot from growing larger and may prevent clots from breaking
off to travel to the lungs – called pulmonary embolism. But
they cannot dissolve clots that already have formed.
A new Interventional Radiology technique called catheter-directed
thrombolysis is a minimally-invasive treatment that breaks
down existing clots that interfere with the normal flow of blood.